Author

Kirsty Roberts

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Alex CaganiD· 3 shared Adrian Baez‐OrtegaiD· 2 shared Andrew R. J. LawsoniD· 2 shared Federico AbascaliD· 2 shared Iñigo MartincorenaiD· 2 shared Matthew D. C. NevilleiD· 2 shared Matthew E. HurlesiD· 2 shared Michael R. StrattoniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Alex CaganORCID

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3 papers

Recent·Most cited

Mutation timing, accumulation and selection in the male germline shape inheritance risk for developmental disorders

Matthew D. C. Neville, Sonja Neuser, Rashesh Sanghvi, Joseph Christopher, Kirsty Roberts, Katie Smith, Laura O’Neill, Joseph Hayes, Alex Cagan, Matthew E. Hurles, Anne Goriely, Rami Abou Jamra, Raheleh Rahbari

The paper investigates how mutation timing, accumulation, and selection in the male germline influence the risk of developmental disorders through de novo mutations.

Cell Genomics · Sep 1, 2026Peer-reviewedGenetic & Genomic Medicine

Sperm sequencing reveals extensive positive selection in the male germline

Matthew D. C. Neville, Andrew R. J. Lawson, Rashesh Sanghvi, Federico Abascal, My H. Pham, Alex Cagan, Pantelis A. Nicola, Tetyana Bayzetinova, Adrian Baez‐Ortega, Kirsty Roberts, Stefanie V. Lensing, Sara Widaa, Raul E. Alcantara, María Paz García, Sam Wadge, , Raheleh Rahbari

This study uses sperm sequencing to show that positive selection in the male germline leads to a higher risk of disease-causing mutations in offspring.

Nature · Oct 8, 2025Peer-reviewedGenetic & Genomic Medicine

Somatic mutation rates scale with lifespan across mammals

Alex Cagan, Adrian Baez‐Ortega, Natalia Brzozowska, Federico Abascal, Tim H. H. Coorens, Mathijs Arnoud Sanders, Andrew R. J. Lawson, Luke M. R. Harvey, Shriram G. Bhosle, David Jones, Raul E. Alcantara, Timothy M. Butler, Yvette E. Hooks, Kirsty Roberts, Elizabeth Anderson, , Iñigo Martincorena

This study finds that somatic mutation rates per year decrease with species lifespan across mammals, suggesting evolutionary constraints on mutagenesis and its role in ageing.

Nature · Apr 13, 2022Peer-reviewedGenomics