APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
Tongwu Zhang, Jian Sang, Phuc H. Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J. Klimczak, John P. McElderry, Alyssa Klein, Christopher Wirth, Erik N. Bergstrom, Marcos Díaz‐Gay, Raviteja Vangara, Frank J. Colón-Matos, Amy A Hutchinson, , Maria Teresa Landi
The paper identifies two lung cancer subtypes defined by APOBEC mutagenesis levels and shows their association with different genetic mutations, aging, and immune responses.
bioRxiv · Apr 2, 2024 · PreprintGenomics