Dmitry A. Gordenin

Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human Body

The paper analyzes somatic mutation profiles in normal human tissues to identify mutagenic mechanisms and their association with age, disease, and environmental exposures.

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types

This study compares genome instability in articular chondrocytes and skin fibroblasts using whole-genome sequencing, revealing distinct mutation patterns and mutagenic mechanisms between the two cell types.

Somatic mutation landscape revealed by non-invasive iPSC derivation from urine cells

This study characterizes somatic mutations in urine-derived iPSCs, showing they reflect age-related genomic changes and can trace developmental lineages non-invasively.

APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses

The paper identifies APOBEC3A as the main RNA editor in human cells and viruses, showing its preference for specific motifs in mRNA and viral RNA.

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast

The paper shows that a hypomorphic mutation in RPA subunit rfa1-t33 in yeast enhances APOBEC-induced mutagenesis and alters mutation spectra.

APOBEC shapes tumor evolution and age at onset of lung cancer in smokers

The paper identifies two lung cancer subtypes defined by APOBEC mutagenesis levels and shows their association with different genetic mutations, aging, and immune responses.

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic

The paper compares mutation spectra between hypermutated rubella virus genomes and SARS-CoV-2 genomes, finding similarities in mutation patterns and suggesting shared mutation mechanisms.

APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

This study identifies TREX1 and APOBEC3B as key drivers of chromothripsis and kataegis during telomere crisis in cancer.

Genomic footprints of activated telomere maintenance mechanisms in cancer

The paper analyzes whole-genome sequencing data from cancer samples to identify genomic footprints of telomere maintenance mechanisms, finding specific telomere variant repeat patterns associated with ATRX/DAXX mutations.

Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.

Process-specific somatic mutation distributions vary with three-dimensional genome structure

The paper examines how somatic mutation distributions vary across chromatin folding domains in cancer genomes, revealing distinct patterns associated with different mutational processes.