Integrated structural dynamics uncover new modes of B12 photoreceptor activation
Ronald Rios-Santacruz, Harshwardhan Poddar, Kévin Pounot, Derren J. Heyes, Nicolas Coquelle, Megan J. Mackintosh, Linus O. Johannissen, Sara Schianchi, Laura N. Jeffreys, Elke De Zitter, Rory Munro, Martin V. Appleby, Danny Axford, Emma V. Beale, Matthew J. Cliff, , Giorgio Schirò
The paper describes the photoactivation mechanism of the B12 photoreceptor CarH using structural and spectroscopic methods, revealing unique intermediates that drive tetramer dissociation.
Nature · Feb 4, 2026Peer-reviewedBiophysics