Enabling reproducible type 1 diabetes polygenic risk scoring for clinical and translational applications
Maizy S. Brasher, Matthew J. Fisher, Carolina Sanchez Wild, Jonathan Shortt, Krista Miller, Randi K. Johnson, Nicholas M. Rafaels, Elizabeth L. Kudron, Ian M. Brooks, Kristy Crooks, Sean M. Oser, Tamara K. Oser, Joanne B. Cole, Laura K. Wiley, Sridharan Raghavan, , Christopher R. Gignoux
This paper develops a pipeline for translating type 1 diabetes polygenic risk scores into clinical use, showing they can distinguish type 1 from type 2 diabetes and identify high-risk individuals.
medRxiv · Jul 15, 2025 · PreprintGenetic & Genomic Medicine