Zebrafish knockout models of atxn1a, atxn1b, and atxn1l reveal distinct and shared phenotypic and transcriptomic alterations
Anwarul Karim, Pramuk Keerthisinghe, Sreeja Sarasamma, Nicholas A. Ciaburri, Mabel Guerra Giraldez, Kylan Naidoo, James Peter Orengo
The paper generates zebrafish knockouts of atxn1a, atxn1b, and atxn1l to study their roles, finding distinct and shared developmental, behavioral, and transcriptomic effects.
bioRxiv · Mar 8, 2026 · PreprintNeuroscience