Anwarul Karim

Zebrafish knockout models of atxn1a, atxn1b, and atxn1l reveal distinct and shared phenotypic and transcriptomic alterations

The paper generates zebrafish knockouts of atxn1a, atxn1b, and atxn1l to study their roles, finding distinct and shared developmental, behavioral, and transcriptomic effects.

Astrocytic L-lactate signaling in the anterior cingulate cortex is essential for schema memory and neuronal mitochondrial biogenesis

This study shows that astrocytic Gi signaling in the ACC reduces L-lactate levels, impairing schema memory and neuronal mitochondrial biogenesis in rats, with L-lactate rescue reversing these effects.

Size matters: large copy number losses reveal novel Hirschsprung disease genes

The paper identifies large copy number losses as contributors to Hirschsprung disease, specifically in HSCR-AAM patients, and validates four genes involved in enteric nervous system development.