Author

Kyle Lam

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Brenda M. RubensteiniD· 1 shared David C. DalgarnoiD· 1 shared Gabriel Monteiro da SilvaiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Brenda M. RubensteinORCID

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1 paper

Recent·Most cited

Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

Gabriel Monteiro da Silva, Kyle Lam, David C. Dalgarno, Brenda M. Rubenstein

This study uses Weighted Ensemble simulations to analyze DFG flip mechanisms in Abl1 kinase and shows how compound mutations increase free energy barriers, leading to inhibitor resistance.

bioRxiv · May 23, 2024 · PreprintBiophysics