Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Historical Cholesterol Exposure
Shoa L. Clarke, Catherine Tcheandjieu, Austin T. Hilliard, Kyung Min Lee, Julie Ann Lynch, Kyong-Mi Chang, Donald R. Miller, VA Million Veteran Program, Joshua W. Knowles, Christopher J. O’Donnell, Philip S. Tsao, Daniel James Rader, Peter W.F. Wilson, Yan V. Sun, J. Michael Gaziano, Themistocles L. Assimes
This study shows that FH genetic variants increase CAD risk even after adjusting for multiple LDL-C measurements from EHRs, indicating LDL-C data alone cannot fully explain the risk.
Circulation Genomic and Precision Medicine · Feb 10, 2022Peer-reviewedGenetic & Genomic Medicine