A computational model of hydrogen peroxide production in liver and its removal by catalase and GSH-reliant enzymes that can predict intracellular H2O2 concentration and cell death during incidents of extreme oxidative stress
The paper develops a computational model of H2O2 metabolism in hepatocytes that predicts intracellular H2O2 concentration and cell death during extreme oxidative stress, incorporating GSH synthesis and xenobiotic exposure dynamics.
bioRxiv · Sep 3, 2023 · PreprintPhysiology