Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8
D. Farhat, F. Rezaei, M. Ristovski, Y. Yang, A. Stancescu, L. Dzimkova, S. Samnani, J.-F. Couture, J.-Y. Lee
This study determines the crystal structure of ABCG5/G8 in a cholesterol-bound state and identifies a conserved phenylalanine array that supports sterol selectivity.
bioRxiv · May 18, 2022Biochemistry