L. Garion

Mechanical strain focusing at topological defect sites in regenerating Hydra

This study shows mechanical strain focuses at topological defects during Hydra regeneration, promoting head organizer formation through a feedback loop involving Wnt signaling and biophysical modeling.

Confinement modulates axial patterning in regenerating Hydra

This study shows that mechanical confinement in Hydra regeneration can lead to multiaxial body plans due to nematic topological defects in actomyosin fibers, challenging the idea that axial patterning relies solely on biochemical gradients.

Canalized morphogenesis driven by inherited tissue asymmetries in Hydra regeneration

This study investigates how inherited tissue asymmetries guide body-axis polarity in Hydra regeneration, showing that mechanical and biochemical feedback lead to reproducible developmental outcomes.

Plasticity of body axis polarity in Hydra regeneration under constraints

The paper studies Hydra regeneration, showing that body axis polarity can be reversed under certain conditions, with head formation biased toward tissue edges due to actin fiber defects.

Topological defects in the nematic order of actin fibers as organization centers of Hydra morphogenesis

The paper identifies topological defects in actin fiber nematic order as organization centers during Hydra morphogenesis, suggesting they function as mechanical morphogens.