Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death
N. Meyer, L. Henkel, B. Linder, S. Zielke, G. Tascher, S. Trautmann, G. Geisslinger, C. Munch, S. Fulda, I. Tegeder, D. Kogel
This study shows that pimozide and loperamide induce glioma cell death through autophagy, lipotoxicity, and lysosomal membrane permeabilization in MZ-54 GBM cells.
bioRxiv · Sep 23, 2020Cancer Biology