Author

G. Geisslinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Schneider· 2 shared D. Thomas· 2 shared J. Cinatl· 2 shared N. Ferreiros· 2 shared O. T. Keppler· 2 shared Y. Xiong· 2 shared B. Bilen· 1 shared B. Linder· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Schneider

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

T. Rothenburger, D. Thomas, Y. Schreiber, P. R. Wratil, T. Pflantz, K. Knecht, K. Digianantonio, J. Temple, C. Schneider, H.-M. Baldauf, K.-M. McLaughlin, F. Rothweiler, B. Bilen, S. Farmand, D. Bojkova, , J. Cinatl

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

bioRxiv · Jul 19, 2021Pharmacology & Toxicology

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

N. Meyer, L. Henkel, B. Linder, S. Zielke, G. Tascher, S. Trautmann, G. Geisslinger, C. Munch, S. Fulda, I. Tegeder, D. Kogel

This study shows that pimozide and loperamide induce glioma cell death through autophagy, lipotoxicity, and lysosomal membrane permeabilization in MZ-54 GBM cells.

bioRxiv · Sep 23, 2020Cancer Biology

Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells

L. Hahnefeld, L. Gruber, N. Schoemel, C. Fischer, P. Mattjus, R. Gurke, M. Beretta, N. Ferreiros Bouzas, G. Geisslinger, M.-S. Wegner

The paper identifies co-expression patterns of lipid classes in breast cancer cells, showing that ether lipids and sphingolipids are upregulated in G-protein coupled estrogen receptor 1-positive cells.

bioRxiv · Jul 20, 2020Cancer Biology

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

K. M. Knecht, O. Buzovetsky, C. Schneider, D. Thomas, V. Srikanth, F. Tofoleanu, K. Reiss, N. Ferreiros, G. Geisslinger, V. S. Batista, X. Ji, J. Cinatl, O. T. Keppler, Y. Xiong

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

bioRxiv · Apr 6, 2018Biochemistry