Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5
I. Callegari, J. Oechtering, M. Schneider, S. Perriot, A. Mathias, M. Voortman, A. Cagol, U. Lanner, M. Diebold, S. Holdermann, V. Kreiner, B. Becher, C. Granziera, A. Junker, R. Du Pasquier, , T. Derfuss
The paper identifies cell-binding IgM in CSF that targets SCARA5 in multiple sclerosis, linking it to complement activation and T cell infiltration.
bioRxiv · Sep 29, 2023Immunology