Compartmentalization of the replication fork by single-stranded DNA binding protein regulates translesion synthesis
S. Chang, E. S. Thrall, L. Laureti, V. Pages, J. J. Loparo
The paper shows that SSB remodeling at stalled replication forks enables Pol IV localization, which is essential for TLS on both strands by overcoming the gatekeeping role of the Pol III epsilon subunit.
bioRxiv · Mar 3, 2020Biochemistry