Theoretical Quantification of the Polyvalent Binding of Nanoparticles Coated with Peptide-MHC to TCR-Nanoclusters
M. Pineros-Rodriguez, L. Richez, A. Khadra
The paper develops a multiscale biophysical model to quantify polyvalent binding of pMHC-coated nanoparticles to TCR nanoclusters and examines its role in T cell activation.
bioRxiv · Mar 4, 2022 · PreprintBiophysics