Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations
M. S. P. Sansom, A. H. Larsen, L. Tata, L. John
This study uses molecular dynamics simulations to reveal how the EEA1 FYVE domain binds to PI(3)P-containing membranes through a hinge mechanism involving specific interactions and flexibility.
bioRxiv · Feb 18, 2021Biophysics