A meta-analysis of clinical cases of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance
L. Tobalina, J. Armenia, E. Irving, M. J. O'Connor, J. V. Forment
This study analyzes reversion mutations in BRCA genes from clinical cases to identify DNA end-joining repair mechanisms linked to therapy resistance and suggests targeting these pathways to improve treatment outcomes.
bioRxiv · Jul 22, 2020Cancer Biology