ERM-Dependent Assembly of T-Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli Prior to Activation
S. Ghosh, V. Di Bartolo, L. Tubul, E. Shimoni, E. Kartvelishvily, T. Dadosh, S. W. Feigelson, R. Alon, A. Alcover, G. Haran
The paper shows that TCR complexes and co-stimulatory molecules are pre-assembled on microvilli via ERM-dependent mechanisms in resting T cells.
bioRxiv · Sep 12, 2019Immunology