Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the Foot-and-Mouth Disease Virus capsid
L. Ferretti, E. Perez, F. Zhang, F. Maree, L.-M. de Klerk-Lorist, L. van Schalkwykc, N. D. Juleff, B. Charleston, P. Ribeca
This paper shows that within-host recombination and epistasis significantly drive molecular evolution of FMDV capsid genes, with recombination rates comparable to mutation rates.
bioRxiv · Dec 12, 2018Microbiology