B. Charleston

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

This study compares the antigenic properties of SARS-CoV-2 Omicron variants BA.4 and BA.5 with BA.1, BA.2, and vaccine-induced antibodies, finding they are antigenically distinct and show enhanced neutralisation breadth after breakthrough infection.

Viral dynamics and immune responses to foot-and-mouth disease virus in African buffalo (Syncerus caffer).

This study investigates FMD virus dynamics and immune responses in African buffalo, showing systemic infection, high viral loads, and strong immune responses despite mild clinical symptoms.

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)

This study shows FMDV binds to follicular dendritic cells via CR2/CR1, leading to sustained neutralising antibody responses in mice.

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

This study shows that convalescent sera from SARS-CoV-2 infected patients efficiently neutralize RaTG13, a close coronavirus relative, more effectively than SARS-CoV-2 itself.

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the Foot-and-Mouth Disease Virus capsid

This paper shows that within-host recombination and epistasis significantly drive molecular evolution of FMDV capsid genes, with recombination rates comparable to mutation rates.