Author

L. Wieske

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Danelius· 2 shared G. Bu· 2 shared T. Gonen· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

E. Danelius

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2 papers

Recent·Most cited

Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED

G. Bu, E. Danelius, L. Wieske, T. Gonen

This paper reports two polymorphic crystal structures of paritaprevir determined by MicroED, showing conformational changes and potential drug-target interactions.

bioRxiv · Sep 9, 2023Biochemistry

MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations

E. Danelius, G. Bu, L. Wieske, T. Gonen

This study uses MicroED to rapidly determine atomic structures of flexible macrocyclic drug compounds from nanogram samples, revealing multiple conformations from a single experiment.

bioRxiv · Jul 31, 2023Biochemistry