Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts
Lilian Petropoulou-Vathi, Athina‐Maria Simitsi, Politymi-Eleni Valkimadi, Maria Kedariti, Lampros Dimitrakopoulos, Christos Koros, Dimitra A. Papadimitriou, Alexandros Papadimitriou, Leonidas Stefanis, Roy N. Alcalay, Hardy J. Rideout
The paper identifies distinct phosphorylation patterns of LRRK2 and Rab GTPases in different Parkinson's disease cohorts, highlighting the need for multiple targets in pharmacodynamic assessments.
npj Parkinson s Disease · Jun 8, 2022Peer-reviewedNeuroscience