Hardy J. Rideout

This study identifies a regulatory feedback loop between LRRK2 and PP2A phosphatases in Parkinson's disease, showing that LRRK2 phosphorylates PP2A to disrupt its function and contribute to neuronal death.

This study identifies early molecular changes in aging mouse sciatic nerve that precede sarcopenia onset, revealing pathways linked to circadian rhythm and metabolic processes.

The paper investigates the relationship between LRRK2 and GCase activities in Parkinson's disease models and biospecimens, finding a positive correlation.

The paper identifies distinct phosphorylation patterns of LRRK2 and Rab GTPases in different Parkinson's disease cohorts, highlighting the need for multiple targets in pharmacodynamic assessments.