Towards selective-alignment: Bridging the accuracy gap between alignment-based and alignment-free transcript quantification
Hirak Sarkar, Mohsen Zakeri, Laraib Malik, Rob Patro
The paper introduces a selective-alignment algorithm to improve transcript-level quantification accuracy while maintaining efficiency, resolving complex mapping scenarios and reducing spurious alignments.
bioRxiv · Aug 24, 2017 · PreprintBioinformatics