Author

Larry Babb

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Approach:benchmark study· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ada HamoshiD· 1 shared Adam L. Felsenfeld· 1 shared Adam W. HanseniD· 1 shared Alicia B. ByrneiD· 1 shared Anne O’Donnell‐LuriaiD· 1 shared Arif O. HarmanciiD· 1 shared Arthur L. BeaudetiD· 1 shared Beryl B. CummingsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenetic & Genomic Medicine

Ada HamoshORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Calibration of in-frame indel variant effect predictors for clinical variant classification

Haneen Abderrazzaq, Mugdha Singh, Larry Babb, Timothy R. Bergquist, Steven E. Brenner, Vikas Rao Pejaver, Anne O’Donnell‐Luria, Predrag Radivojac A, ClinGen Computational Working Group, ClinGen Variant Classification Working Group

This study calibrates in-frame indel variant effect predictors for clinical classification, showing they reach multiple evidence levels but perform worse than missense predictors.

bioRxiv · Apr 18, 2026 · PreprintBioinformatics

Centers for Mendelian Genomics: A decade of facilitating gene discovery

Samantha M. Baxter, Jennifer Ellen Posey, Nicole J. Lake, Nara Lygia de Macena Sobreira, Jessica X. Chong, Steven G. Buyske, Elizabeth Blue, Lisa Helbling Chadwick, Zeynep Coban‐Akdemir, Kimberly Floy Doheny, Colleen P. Davis, Monkol Lek, Christopher Wellington, Shalini N. Jhangiani, Mark Gerstein, , Kurt N. Hetrick

The paper describes the role of the Centers for Mendelian Genomics in advancing gene discovery through data sharing, collaboration, and resource development over the past decade.

Genetics in Medicine · Feb 8, 2022Peer-reviewedGenetic & Genomic Medicine