Author

Haneen Abderrazzaq

Northeastern UniversityORCID 0009-0004-3554-1576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

Anne O’Donnell‐LuriaiD· 2 shared Predrag Radivojac AiD· 2 shared Ben WeisburdiD· 1 shared Benjamin M. NealeiD· 1 shared Calwing LiaoiD· 1 shared Christopher Vittal· 1 shared ClinGen Computational Working Group· 1 shared ClinGen Variant Classification Working Group· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Anne O’Donnell‐LuriaORCID

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2 papers

Recent·Most cited

Calibration of in-frame indel variant effect predictors for clinical variant classification

Haneen Abderrazzaq, Mugdha Singh, Larry Babb, Timothy R. Bergquist, Steven E. Brenner, Vikas Rao Pejaver, Anne O’Donnell‐Luria, Predrag Radivojac A, ClinGen Computational Working Group, ClinGen Variant Classification Working Group

This study calibrates in-frame indel variant effect predictors for clinical classification, showing they reach multiple evidence levels but perform worse than missense predictors.

bioRxiv · Apr 18, 2026 · PreprintBioinformatics

The landscape of regional missense mutational intolerance quantified from 730,947 exomes

Lily Wang, Katherine R. Chao, Ruchit Panchal, Calwing Liao, Haneen Abderrazzaq, Robert Ye, Patrick Schultz, John Compitello, Riley H. Grant, Jack A. Kosmicki, Ben Weisburd, William Phu, Michael W. Wilson, Kristen M. Laricchia, Julia K. Goodrich, , Kaitlin E. Samocha

The paper quantifies regional missense mutational intolerance using 730,947 exomes to identify constrained gene regions and improve variant interpretation.

bioRxiv · Apr 11, 2024 · PreprintGenomics