Improvement of the potency of a N1-methylpseudouridine-modified self-amplifying RNA through mutations in the RNA-dependent-RNA-polymerase
Verónica M. Quintana, Josefina Caillava, Laura A. Byk, Juan A. Mondotte, Leandro Battini, Prutha Tarte, Marcelo M. Samsa, Claudia V. Filomatori, Diego Ezequiel Alvarez
This study improves the potency of N1-methylpseudouridine-modified self-amplifying RNA by identifying mutations that enhance RNA synthesis and antigen expression.
Journal of Biological Chemistry · Jul 17, 2025Peer-reviewedMolecular Biology