Gasdermin D deficiency attenuates development of ascending aortic dissections in a novel mouse model
Muhammad J. Javed, Rachael M. Howard, Hua Li, Laura Carrasco, Marvin L. S. Dirain, Gang Su, Guoshuai Cai, Gilbert R. Upchurch, Zhihua Jiang
This paper develops a novel mouse model of ascending aortic dissection and shows that Gsdmd deficiency reduces dissection severity by modulating cell death and T-cell responses.
Arteriosclerosis Thrombosis and Vascular Biology · Feb 13, 2025Peer-reviewedPhysiology