Author

Marvin L. S. Dirain

University of Florida Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Guoshuai CaiiD· 3 shared Alicia M. MohriD· 2 shared Angel M. CharlesiD· 2 shared Christine E. RodhouseiD· 2 shared Clayton E. MathewsiD· 2 shared Feifei XiaoiD· 2 shared J. M. Castro RincóniD· 2 shared Leilani Zeumer-Spataro· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Guoshuai CaiORCID

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3 papers

Recent·Most cited

Divergent chromatin remodeling in post-sepsis MDSCs underlies MHC class II repression in CCI

Jason Orr Brant, Marie‐Pierre L. Gauthier, Christine E. Rodhouse, Ruoxuan Wu, Miguel Hernández-Ríos, Leilani Zeumer-Spataro, Marvin L. S. Dirain, Ricardo F. Ungaro, Ivanna L. Rocha, Whittman B. Wiggins, Angel M. Charles, Feifei Xiao, Letitia E. Bible, Alicia M. Mohr, Shawn D. Larson, , Michael P. Kladde

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

Christine E. Rodhouse, Dayuan Wang, Hongru Tang, Valerie E. Polcz, Miguel Hernández-Ríos, Xuanxuan Yu, Leandro Balzano‐Nogueira, Jaimar C. Rincon, Angel M. Charles, Seiichiro Fujishima, Quan Vo, Marvin L. S. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, , Philip Alexander Efron

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

bioRxiv · Oct 6, 2025 · PreprintImmunology

Gasdermin D deficiency attenuates development of ascending aortic dissections in a novel mouse model

Muhammad J. Javed, Rachael M. Howard, Hua Li, Laura Carrasco, Marvin L. S. Dirain, Gang Su, Guoshuai Cai, Gilbert R. Upchurch, Zhihua Jiang

This paper develops a novel mouse model of ascending aortic dissection and shows that Gsdmd deficiency reduces dissection severity by modulating cell death and T-cell responses.

Arteriosclerosis Thrombosis and Vascular Biology · Feb 13, 2025Peer-reviewedPhysiology