Rewriting protein alphabets with language models
Lorenzo Pantolini, Gabriel Studer, Laura Engist, Ieva Pudžiuvelytė, Florian Pommerening, Andrew Mark Waterhouse, Stefan Bienert, Gerardo Tauriello, Martin Steinegger, Torsten F. Schwede, Janani Durairaj
This paper introduces a new 20-letter alphabet, TEA, derived from protein language models, enabling efficient homology searches comparable to structure-based methods without structural data.
bioRxiv · Nov 27, 2025 · PreprintBioinformatics