A habenula-enriched GPCR, GPR151, regulates behavioral sensitivity to inflammation
Lupita Rios, You‐Hsin Lin, Laura Yuan, Yash Sharma, Hailey Arias, Fizza Jeddy, Sravya Thotakura, Aiden Geleta, Raghav Rajesh, Steven J. Shabel
This study identifies GPR151 as a habenula-specific GPCR that modulates behavioral responses to inflammation, with potential therapeutic implications for inflammation-associated depression.
bioRxiv · Aug 7, 2026 · PreprintNeuroscience