Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations
Yuwei Cao, Lauren Patel, Lauren Alcoser, Eric M. Mendenhall, Christopher W. Benner, Sven Heinz, Alon Goren
The paper introduces spa-ChIP-seq, an automated ChIP-seq protocol, showing it achieves comparable signal-to-noise ratios to manual methods and identifies sensitivity of weak signals to antibody-to-cell-number ratio changes.
Genome Research · Dec 12, 2025Peer-reviewedGenomics