Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation
Gregory R. Keele, Bryan C. Quach, Jennifer W. Israel, Grace A. Chappell, Lauren Lewis, Alexias Safi, Jeremy M. Simon, Paul A. Cotney, Gregory E. Crawford, William S. J. Valdar, Ivan Rusyn, Terrence S. Furey
The paper identifies genetic regulators of gene expression and chromatin accessibility across multiple tissues using a genetically diverse mouse population and proposes a causal model for gene regulation.
PLoS Genetics · Jan 21, 2020Peer-reviewedGenomics