Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell Lines
Hratch Baghdassarian, Pablo Di Giusto, Juan D. Tibocha‐Bonilla, Erick Armingol, Saratram Gopalakrishnan, Leo Alexander Dworkin, Laurence M Yang, Nathan E. Lewis
The paper develops human ME-Models that integrate gene expression and metabolism, showing improved growth-rate predictions and biological plausibility in cancer cell lines.
bioRxiv · Jun 3, 2026 · PreprintSystems Biology