Author

Leo Alexander Dworkin

University of GeorgiaORCID 0000-0001-7185-6680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Nathan E. LewisiD· 3 shared Hooman HefziiD· 2 shared Lars Keld NielseniD· 2 shared Pablo Di GiustoiD· 2 shared Saratram GopalakrishnaniD· 2 shared Ana María Vega-LetteriD· 1 shared Anne RichelleiD· 1 shared Athanasios AntonakoudisiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSystems Biology

Nathan E. LewisORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintJun 3, 2026

Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell Lines

Hratch Baghdassarian, Pablo Di Giusto, Juan D. Tibocha‐Bonilla…·Nathan E. Lewis

The paper develops human ME-Models that integrate gene expression and metabolism, showing improved growth-rate predictions and biological plausibility in cancer cell lines.

DOI 10.64898/2026.05.30.728988

humanbulk RNA-seq

𝕏 PostBluesky

BioengineeringbioRxivPreprintFeb 18, 2026

The Role of Glycan Structures in Modulating GM-CSF Bioactivity: Insights from Glycoengineering

Ece Çağdaş, Sarah Line Skovbakke, Judit Pina Agullet…·Nathan E. Lewis

This study investigates how glycan structures affect GM-CSF bioactivity by engineering glycoforms in Chinese hamster ovary cells and testing their effects on TF-1 cell proliferation.

DOI 10.64898/2026.02.17.706267

humanproteomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintApr 10, 2025

A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells

Pablo Di Giusto, Dong‐Hyuk Choi, Athanasios Antonakoudis…·Nathan E. Lewis

The paper presents iCHO3K, a comprehensive metabolic model of Chinese Hamster cells, and uses it to analyze metabolic changes in lactate-free cells, identifying structural insights into metabolic rewiring.

3 citations

mousemetabolomics

𝕏 PostBluesky