Within-host evolution of Klebsiella spp. from intestinal carriage to bacteremia
Cécile Gosset, Olaya Rendueles, Nicolas Charbonnel, Caroline Massit, Laurence Nakusi, Damien Balestrino, Richard Bonnet, Pierre Saint-Sardos, Christiane Forestier, Bertrand Souweine, Sylvie Miquel
This study analyzes Klebsiella strains from ICU patients to show that within-host genetic changes, not virulence traits, drive progression from gut colonization to bloodstream infections.
bioRxiv · Jan 5, 2026 · PreprintMicrobiology