The fecal microbiota transplantation from drug-naive schizophrenia patients distinctively changes gut microbiome and metabolic profiles in male and female mice
Raghunath Singh, Sandra Pereira, Kristoffer J. Panganiban, Laurie Hamel, David Charles Wright, Thomas D. Prévot, Daniel J. Müller, Gary J. Remington, Sri Mahavir Agarwal, Přemysl Berčík, Elena Francisca Verdu, Giada De Palma, Margaret Hahn
This study uses fecal microbiota transplantation from schizophrenia patients in mice to show sex-specific effects on gut microbiome and metabolic profiles, particularly insulin resistance and short-chain fatty acid changes in females.
bioRxiv · Sep 13, 2025 · PreprintNeuroscience