Thomas D. Prévot

This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.

This study investigates the role of IFN-γ receptor signaling in SST interneurons, showing it supports normal behavior and molecular homeostasis while mediating inflammation-induced deficits.

This study uses fecal microbiota transplantation from schizophrenia patients in mice to show sex-specific effects on gut microbiome and metabolic profiles, particularly insulin resistance and short-chain fatty acid changes in females.

This study investigates how central leptin affects energy homeostasis and metabolism in rats exposed to olanzapine, finding that leptin's effects on food intake and fat oxidation are not blocked by olanzapine.

This study shows that spine loss in depression impairs dendritic signal integration in human cortical microcircuits, leading to greater functional impairment than reduced inhibition alone.

This study predicts optimal 5-PAM doses for depression treatment using simulated EEG data and machine learning models.

This study identifies distinct EEG biomarkers for 5-PAM in rodents, showing specific changes in theta and beta/gamma power compared to diazepam.

The paper shows that 5-GABA-A receptor positive allosteric modulation improves neuronal morphology and cognitive function in a mouse model of tauopathy without affecting p-Tau levels.

This study shows that LPS-induced inflammation reduces GABAergic interneuron markers and BDNF in mouse prefrontal cortex and hippocampus, suggesting a link to MDD pathophysiology.

This study shows that extrasynaptic localization of 5GABAARs is critical for their ability to modulate dopamine system function, as shifting them to synaptic locations abolishes the effect of the 5-PAM GL-II-73.

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

This study examines age-related changes in brain structure and cognition in mice, finding volume and network differences associated with maturation and aging.

This study evaluates the effects of GABAA receptor modulators in a mouse model of chronic stress, showing antidepressant and pro-cognitive effects with neurotrophic benefits.

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

This study examines how chronic stress affects behavior and molecular markers in mice, showing gender-specific differences in molecular responses and behavioral outcomes.

This study shows that chronic stress increases neuronal activation in specific brain regions in response to acute stress, which correlates with behavioral deficits in mice.

This study shows that chronic treatment with a 5-GABA-A receptor PAM increases dendritic length, spine count, and density in mice, suggesting potential for reversing age-related cognitive decline.

This study identifies three novel GABAA receptor modulators that show anxiolytic, antidepressant, and pro-cognitive effects in mice, unlike diazepam.