Dynamic thermodynamic-informational entropic relationship (TIER) models of selective vulnerability to neurodegeneration
Peter Pressman, Cemal Basaran, Peter W. Foltz, Wan-Tai Michael Au-Yeung, Joel Steele, Lisa C. Silbert, Lawrence E Hunter
The paper develops TIER models to explain selective vulnerability in neurodegeneration by linking computational workload, thermodynamic entropy, and structural failure in neural networks.
bioRxiv · Apr 11, 2026 · PreprintNeuroscience