Lisa C. Silbert

This study shows that aging rhesus macaques exhibit age-dependent perivascular space burden, mirroring human patterns, and validates MRI-detected structures as perivascular spaces.

The paper develops TIER models to explain selective vulnerability in neurodegeneration by linking computational workload, thermodynamic entropy, and structural failure in neural networks.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

The paper examines GPR39 localization in aged human brains and correlates its expression and polymorphism with vascular cognitive impairment.

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.