Exploiting Index Cross-Talk to Modify Variant Calls
Peter M. Ney, Lee Organick, Karl Koscher, Tadayoshi Kohno, Luis Ceze
The paper demonstrates how index cross-talk in DNA sequencing can be exploited to modify variant calls, showing a wild-type exome misclassified as heterozygous at the sickle-cell locus.
bioRxiv · May 28, 2018 · PreprintBioengineering