JAK and TYK2 inhibitors differentially modulate interferon/TNF-driven inflammation, stemness and proliferation in the colonic epithelium of ulcerative colitis
Arun Sridhar, Gunnar Andreas Walaas, Siri Sæterstad, Johan Pierre Durand Myrmehl, Romana Cermakova, Marte Gisvold Myrseth, Leona Grundel, Marianne Doré Hansen, Marianne Otterstad, Marte Lie Høivik, Ann Elisabet Østvik, Ingunn Bakke, Torunn Bruland
This study examines how JAK/TYK2 inhibitors affect epithelial responses in UC, showing differential modulation of inflammation, stemness, and proliferation.
bioRxiv · Jul 20, 2026 · PreprintMolecular Biology