Marte Lie Høivik

This study examines how JAK/TYK2 inhibitors affect epithelial responses in UC, showing differential modulation of inflammation, stemness, and proliferation.

This study profiles the B cell repertoire in treatment-naive Crohn's disease patients and controls, finding reduced diversity, increased clonality, and altered immunoglobulin clonotype expansions.

The paper profiles T cell receptor alpha repertoires in IBD patients across multiple cohorts, identifies disease-associated clonotypes, and validates findings in an independent dataset.

This study evaluates how methodological choices in bulk TCR-Seq affect T cell repertoire profiling, finding that RNA/DNA quality significantly impacts results and that low quantities can be partially compensated by increasing PCR cycles.

The paper identifies and validates T cell receptor clonotypes associated with Crohn's disease and ulcerative colitis, suggesting they are potential therapeutic targets.

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.