Nucleolar and Chromatin Remodeling during γ-Irradiation-Induced Mitotic Catastrophe: Live-Cell Imaging Correlated with UBTF and Fibrillarin 3D Redistribution
Natia Makhatadze, Lili Nadaraia, M. Gogebashvili, Mikheil Nanikashvili, V. Okuneva, Nazi Ivanishvili, Levan Rusishvili, Pavel Tchelidze
This study uses live-cell imaging to track nuclear and nucleolar changes during γ-irradiation-induced mitotic catastrophe and apoptosis in HeLa cells, revealing distinct stages of nuclear deformation and nucleolar remodeling.
bioRxiv · Aug 20, 2025 · PreprintCell Biology