Caveolin-1 Mediated Blood-brain Barrier Transcytosis Promotes Porphyromonas gingivalis Invasion and Alzheimer's Disease-Like Changes
Mei Chenghan, Qixing Zhong, Li Xiaojie, He Yao, Ting Zhang, Bangcheng Zhao, Liu Jiangshang, Zhong Zhihui
This study shows that a leaky blood-brain barrier, mediated by caveolin-1 transcytosis, allows Porphyromonas gingivalis to enter the brain, leading to Alzheimer's disease-like changes.
bioRxiv · Feb 18, 2026 · PreprintNeuroscience