TP53 copy number expansion correlates with the evolution of increased body size and an enhanced DNA damage response in elephants
Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P. Mongan, Richard D. Emes, Vincent J. Lynch
This paper shows that elephants have 20 TP53 copies, linked to large body size and enhanced DNA damage response, resolving Petos Paradox.
bioRxiv · Sep 6, 2016Genetics