Author

Vincent J. Lynch

Primary ORCID profile (0000-0001-5311-3824 · 7 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Vincent J. LynchiD7 papers · University of Chicago

Biology Disciplines

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Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Günter P. Wagner· 1 shared Heather L. Darling· 1 shared Jens Meiler· 1 shared Katelyn Mika· 1 shared Laura S. Mizoue· 1 shared Lindsey Fong· 1 shared Lisa Yon· 1 shared Mauris C. Nnamani· 1 shared

Activity by Year

2015-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

Günter P. Wagner

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2 papers

Recent·Most cited

TP53 copy number expansion correlates with the evolution of increased body size and an enhanced DNA damage response in elephants

Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P. Mongan, Richard D. Emes, Vincent J. Lynch

This paper shows that elephants have 20 TP53 copies, linked to large body size and enhanced DNA damage response, resolving Petos Paradox.

bioRxiv · Sep 6, 2016Genetics

Evolution of Conditional Cooperativity Between HOXA11 and FOXO1 Through Allosteric Regulation

Mauris C. Nnamani, Soumya Ganguly, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner

This study investigates how the functional interaction between HOXA11 and FOXO1 evolved through allosteric regulation, showing TF function can change via modifications to pre-existing protein complexes.

bioRxiv · Jan 26, 2015 · PreprintEvolutionary Biology