Transient histone deacetylase inhibition reveals cell type invariant and specific effects of chromatin decondensation on irradiation response
Heng Li, Campbell Maben, Lindsey Young, Debjani Pal, Sandra Davern, Rachel Patton McCord
This paper shows that transient HDAC inhibition increases DNA damage and reduces cell viability in both cancerous and healthy breast cells after high-dose radiation, but effects vary with radiation dose and cell type.
Frontiers in Cell and Developmental Biology · Aug 31, 2026Peer-reviewedCancer Biology